Quantitative functionalization of biosynthetic caged protein materials

Background: As one of the representative protein materials, nanocages (PNCs) are self-assembled supramolecular structures with multiple advantages, such as good monodispersity, biocompatibility, structural addressability, and facile production. Precise quantitative functionalization is essential to construction PNCs designed purposes. Results: With three modifiable interfaces, interior surface, outer interfaces between building blocks, can serve an ideal platform for precise multi-functionalization studies applications. This review summarizes currently available methods highlights significance control in fabricating PNC-based materials or devices. These be categorized into groups, genetic, chemical, combined modification. Conclusion: would constructive those who work biosynthetic diverse fields.